Anti-MCM2 (Human) mAb
Anti-MCM2 (Human) mAb Specifications
|Background:||Minichromosome Maintenance (MCM) proteins play an essential role in eukaryotic DNA replication. Six MCM proteins (MCM2-7) have been identified from yeast to mammals. In human cells, MCM4, -6, and -7 proteins form a stable complex, and MCM2 is loosely associated with this complex. The heterotrimeric MCM complex containing MCM4, -6 and -7 has DNA helicase activity, and such activity can be inhibited by the presence of MCM2. Cdc7/Dbf4 protein kinase, which is required for the initiation of DNA replication phosphorylates MCM2 in vitro and in vivo. From these observations, itâ€™s thought that phosphorylation of MCM2 may remove MCM2 from the MCM4, -6, and -7 complex to activate its DNA helicase activity at the onset of DNA replication.
|Formulation:||1 mg/mL in PBS/50% glycerol, pH 7.2|
|Gene ID Human:||4171|
|Gene ID Mouse:||17216|
|Immunogen:||Recombinant Human fulll length MCM2|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Anti-MCM2 (Human) mAb at this time.