Solutions for Life Science & Diagnostics
Anti-Caspase-5 mAb
Additional Information
Anti-Caspase-5 mAb Specifications
| Background: | Apoptosis is a major form of cell death characterized by morphological features including chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-5 (also known as ICErel-III or ICH-3) is a ~47 kDa member of the ICE/CED-3 family of cysteine proteases. This protein has 51% sequence identity with human interleukin-1-ï¢- converting enzyme, 27% sequence identity with ICH-1L, 30% identity with human CPP32, and 24% sequence identity with the C. elegans CED-3 polypeptide. This ICE subfamily of caspase includes caspase-1, caspase-5, caspase-4, and caspase-13, and appears to play a primary role in cytokine maturation and inflammation. |
| Clonality: | Monoclonal |
| Clone Number: | 4F7 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 838 |
| Host Species: | Mouse |
| Immunogen: | Recombinant C-terminal Caspase-5 (202-419 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | caspase-5 |
Applications: WB
| WB: | 1 μg/mL (for chemiluminescence detection system) |
There are no references for Anti-Caspase-5 mAb at this time.
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