Solutions for Life Science & Diagnostics
Anti-Caspase-8 (Human) mAb
Additional Information
Anti-Caspase-8 (Human) mAb Specifications
| Background: | Caspase-8 (FLICE/MACH/Mch5) is a member of the ICE (interleukin-ï€±ï€ converting enzyme)/CED-3 family cysteine protease. It is the most upstream protease that receives the activation signal from the Fas (APO1/CD95) and TNFR1 (Tumor Necrosis Factor Receptor 1) to initiate the apoptotic protease cascade that leads to activation of ICE/CED-3 family proteases. Caspase-8 has high homologous region to the ICE/CED-3 family in C-terminal and two death effecter domains (DED) in N-terminal. Binding of caspase-8 to FADD (MORT1) through association of their DED, and consequent activation of the caspases by their proteolytic cleavage, are thought to be critical steps in the initiation of Fas- and TNFR1-induced apoptosis. Recently the inhibitor of Fas- and TNFR1-induced apoptosis is identified, called I-FLICE (FLIP/Casper/FLAME/CASH). I-FLICE has high homology to caspase-8 and it contains two DED, which interacts with caspase-8 and FADD, and potently inhibits Fas- and TNFR1-induced apoptosis. |
| Clonality: | Monoclonal |
| Clone Number: | 5D3 |
| Formulation: | 1 mg/mL in PBS/50% glycerol |
| Gene ID Human: | 22861 |
| Gene ID Mouse: | 12370 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human Caspase-8 (C-terminal 180-480 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | caspase-8 |
Applications: IP, WB
| IPP: | 1 ug/200 uL of cell extract from 2.5 x 10 6 |
| WB: | 1 ug/mL |
There are no references for Anti-Caspase-8 (Human) mAb at this time.
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