Anti-Caspase-8 (Human) mAb
Anti-Caspase-8 (Human) mAb Specifications
|Background:||Caspase-8 (FLICE/MACH/Mch5) is a member of the ICE (interleukin-ï€±ï€ converting enzyme)/CED-3 family cysteine protease. It is the most upstream protease that receives the activation signal from the Fas (APO1/CD95) and TNFR1 (Tumor Necrosis Factor Receptor 1) to initiate the apoptotic protease cascade that leads to activation of ICE/CED-3 family proteases. Caspase-8 has high homologous region to the ICE/CED-3 family in C-terminal and two death effecter domains (DED) in N-terminal. Binding of caspase-8 to FADD (MORT1) through association of their DED, and consequent activation of the caspases by their proteolytic cleavage, are thought to be critical steps in the initiation of Fas- and TNFR1-induced apoptosis. Recently the inhibitor of Fas- and TNFR1-induced apoptosis is identified, called I-FLICE (FLIP/Casper/FLAME/CASH). I-FLICE has high homology to caspase-8 and it contains two DED, which interacts with caspase-8 and FADD, and potently inhibits Fas- and TNFR1-induced apoptosis.
|Formulation:||1 mg/mL in PBS/50% glycerol|
|Gene ID Human:||22861|
|Gene ID Mouse:||12370|
|Immunogen:||Recombinant Human Caspase-8 (C-terminal 180-480 a.a.)|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: IP, WB
|IPP:||1 ug/200 uL of cell extract from 2.5 x 10 6|
There are no references for Anti-Caspase-8 (Human) mAb at this time.