Solutions for Life Science & Diagnostics
Anti-Insulin Receptor Substrate p53 (IRSp53) (Human) mAb
Additional Information
Anti-Insulin Receptor Substrate p53 (IRSp53) (Human) mAb Specifications
| Background: | Insulin-dependent phosphorylation occurs at multiple sites near the carboxyl terminus and in the kinase domain. The receptor tyrosine kinase has been implicated as the mediator of the effects of insulin. Insulin receptor tyrosine kinase catalyses the phosphorylation of one or more cell proteins. Yeh et al. reported that 58/53-kDa proteins (also calls Insulin Receptor Substrate p53; IRSp53) obtained from Chinese hamster ovary cells could be tyrosine phosphorylated in insulin-treated cells, and can also be tyrosine phosphorylated in vitro by the isolated human insulin receptor. Human-originated immunogen of this antibody, which is selected by using a domain of Fas Ligand cell, is homologous to the hamster-originated 58/53-kDa proteins reported by Yeh et al. |
| Clonality: | Monoclonal |
| Clone Number: | 3F2 |
| Formulation: | This antibody is lyophilized form. Prepare a stock solution by dissolving the lyophilized antibody with 100 mL of distilled water. After reconstitution, IgG concentration should be 1 mg/mL in PBS (pH 7.2)/1% Sucrose. No preservative is contained. |
| Gene ID Human: | 55971 |
| Gene ID Mouse: | 66898 |
| Host Species: | Mouse |
| Immunogen: | Recombinant human IRSp53_C corresponding to N-terminal portion (1-363 aa) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | IRTKS |
Applications: IC, WB
| ICC: | 5-10 ug/mL |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Insulin Receptor Substrate p53 (IRSp53) (Human) mAb at this time.
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