Solutions for Life Science & Diagnostics
Anti-Bag-1 (Mouse) mAb
Additional Information
Anti-Bag-1 (Mouse) mAb Specifications
| Background: | Bcl-2 and its family members control cell death. Bcl-2, Bcl-xL and Mcl-1 inhibit apoptosis, while Bad, Bax, Bak, Bik and Bcl-xS promote apoptosis in several conditions. Bag-1 cDNA was identified as a Bcl-2 binding protein, which lacks sequence homology with Bcl-2, and its related proteins. Bag-1 enhances the anti-apoptotic activity of Bcl-2. Bag-1 specifically interacts with Raf-1 kinase in vitro and in yeast two hybrid assays. It suggests that Bag-1 joins Ras and 14-3-3 proteins as potential activators of the Raf-1 kinase. Moreover Bag-1 binds to the intracellular domain of the hepatocyte growth factor (HGF) receptor, suggesting that enhances protection from apoptosis. These suggest that Bag-1 represents a new type of anti-cell death gene and that routes of apoptosis induction previously ascribed to Bcl-2 independent pathway may instead reflect a need for the combination of Bcl-2 and Bag-1. |
| Clonality: | Monoclonal |
| Clone Number: | 4A2 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 573 |
| Gene ID Mouse: | 12017 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Mouse Bag-1 (1-220 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Bag-1 |
Applications: WB
| WB: | 1μg/mL |
There are no references for Anti-Bag-1 (Mouse) mAb at this time.
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