Solutions for Life Science & Diagnostics
Anti-14-3-3β/σ (Rat) mAb
Additional Information
Anti-14-3-3β/σ (Rat) mAb Specifications
| Background: | 14-3-3 was first described as an　abundant acidic protein in brain composing 1% of the total　soluble protein. The 14-3-3 family of proteins are　expressed in all eukaryotic cells. There are at least seven　highly conserved isoforms encoded by different gene　products. These proteins have molecular weights of　29,000–32,000 and bind numerous cytoplasmic and　nuclear signaling molecules including such as Raf, protein kinase C, p130Cas, BAD, and phosphatidylinositol 3-kinase. Interaction of 14-3-3 proteins with signaling molecules can localize, activate, inhibit, or stabilize the target molecules. Because 14-3-3 proteins are homo- and heterodimers, they have been considered as adaptor proteins that recruit and regulate the function of signaling molecules. They have been implicated in regulation of cell proliferation, cell cycle progression, apoptosis, and differentiation. |
| Clonality: | Monoclonal |
| Clone Number: | 4E1 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Rat14-3-3β |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | 14-3-3 Beta/sigma |
Applications: IP, WB
| IPP: | 5-10 μg/200 μL of cell extract from 5x106 |
| WB: | 1-5 μg/mL |
There are no references for Anti-14-3-3β/σ (Rat) mAb at this time.
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