HLA-G Monoclonal Antibody

Datasheet:

Gene/antigen ID number:

3135

Background:

Human leukocyte antigen G (HLA-G) is a nonclassical MHC class I antigen with very little sequence variability. HLA-G modulates innate immunity by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G is also an effective ligand of natural killer (NK) inhibitory receptors, and it down-regulates both CD8+ and CD4+ T-cell responsiveness. HLA-G is primarily expressed on fetal cells of the human placenta, suggesting a key role for HLA-G during pregnancy in maintaining immune tolerance at the maternal-fetal interface. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from antitumor immune responses.

Size:

100 μg

Application:

FCM

Clone Number:

87G

Conjugate:

protein A agarose

Product Type:

Primary Antibody

Host Species:

Mouse

Species Reactivities:

Human

Species Reactivities:

Mouse

Isotype:

IgG1

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

Related Products:

K0019-1 Anti-HLA-DR (LN-3) K0125-3 Anti-HLA-G (MEM-G/1) K0126-3 Anti-HLA-E (MEM-E/02) K0186-3 Anti-HLA-A2 (BB7.2) K0186-4 FITC labeled Anti-HLA-A2 (BB7.2) K0186-5 PE labeled Anti-HLA-A2 (BB7.2) K0208-3 Anti-HLA-A24 (17A10) K0208-4 FITC labeled Anti-HLA-A24 (17A10) K0208-5 PE labeled Anti-HLA-A24 (17A10) K0209-3 Anti-HLA-A24 (22E1) K0209-4 FITC labeled Anti-HLA-A24 (22E1) K0209-5 PE labeled Anti-HLA-A24 (22E1) K0215-3 Anti-HLA-E (4D12) D226-3 Anti-HLA-class I (HLA-A,B,C) (EMR8-5)

References:

Bahri, R., et al., J. Immunol. 176, 1331-1339 (2006) Derrien, M., et al., J. Gen. Virol. 85, 1945-1954 (2004) Barel, M. T., et al., J. Immunol. 171, 6757-6765 (2003) Morales, P. J., et al., J. Immunol. 171, 6215-6224 (2003) Ishitani, A., et al., J. Immunol. 171, 1376-1384 (2003) Lenfant, F., et al., J. Gen. Virol. 84, 307-317 (2003) Wiendl, H., et al., J. Immunol. 168, 4772-4780 (2002) Lila, N., et al., PNAS 98, 12150-12155 (2001) Ibrahim, E. C., et al., Cancer Res. 61, 6838-6845 (2001) Onno, M., et al., J. Immunol. 164, 6426-6434 (2000) Jun, Y., et al., J. Immunol. 164, 805-811 (2000) Paul, P., et al., Cancer Res. 59, 1954-1960 (1999) Mallet, V., et al., Int. Immunol. 11, 889-898 (1999) Yang, Y., et al., J. Immunol. 156, 4224-4231 (1996) Lee, N., et al., Immunity 3, 591-600 (1995)

Reactivity:

This antibody reacts with HLA-G on Flow cytometry. This antibody (clone 87G) recognizes membrane-bound HLA-G1 and soluble isoform HLA-G5 molecules and shows no apparent cross-reactivity with other class I molecules when tested on diverse HLA class I-transfected cells.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

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