Caspase-12 (14F4) Monoclonal Antibody

Datasheet:

K0207-3ver2.pdf

( Email this file )

Gene/antigen ID number:

120329

Target:

Caspase-12

Background:

Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid- and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.

Size:

100 μg

Application:

WB

Application:

IPP

Application:

IC

Clone Number:

14F4

Conjugate:

protein G agarose

Product Type:

Primary Antibody

Host Species:

Rat

Species Reactivities:

Human

Species Reactivities:

Mouse

Species Reactivities:

Rat

Isotype:

IgG1

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

Pictures:

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References:

1) Morishima, N., et al., J. Biol. Chem. 277, 34287-34294 (2002)
2) Nakagawa, T., et al., J. Cell. Biol. 150, 887-894 (2000)
3) Nakagawa, T., et al., Nature 403, 98-103 (2000)

Reactivity:

This antibody reacts with Caspase-12(~53 kDa) on Western blotting, Immunoprecipitation andImmunocytochemistry.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

Product Catalog

Caspase-12 (14F4) Monoclonal Antibody

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