Solutions for Life Science & Diagnostics
Anti-Caspase-12 mAb
Additional Information
Anti-Caspase-12 mAb Specifications
| Background: | Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-ï¢, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid-ï¢ and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form. |
| Clonality: | Monoclonal |
| Clone Number: | 14F4 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 120329 |
| Gene ID Mouse: | 12364 |
| Host Species: | Rat |
| Immunogen: | Recombinant Caspase-12 N-terminal fragmen (95-318 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Caspase-12 |
Applications: IC, IP, WB
| ICC: | 10 ug/mL |
| IPP: | 10 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Caspase-12 mAb at this time.
Product Images
