Solutions for Life Science & Diagnostics
Anti-PML (Mouse) mAb
Additional Information
Anti-PML (Mouse) mAb Specifications
| Background: | PML (promyelocytic leukemia) protein is a tripartite motif (TRIM)-containing nuclear phosphoprotein that functions as a transcription factor, a coactivator of nuclear receptors, a regulator of apoptosis, and as a growth and tumor suppressor. PML is localized to the nucleoplasm in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). At least 14 splice variants of PML ranging in molecular weight from 48-97 kDa have been described. All isoforms of PML contain an identical N-terminus but vary in the C-terminal portion of the protein. PML is frequently overexpressed in Hodgkin’s and Reed-Sternberg cells of Hodgkin’s disease. PML is useful in studying acute promyelocytic leukemia which is characterized by fusion of PML and Retinoic Acid Receptor-ï¡ genes. The fusion protein blocks the terminal differentiation of hematopoietic cells and apoptosis. |
| Clonality: | Monoclonal |
| Clone Number: | 36-1-104 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH7.2 |
| Gene ID Human: | 5371 |
| Gene ID Mouse: | 18854 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Mouse PML |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | PML |
Applications: IC, WB
| ICC: | 1 ug/mL |
| WB: | 1 ug/mL |
There are no references for Anti-PML (Mouse) mAb at this time.
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