Solutions for Life Science & Diagnostics
Anti-HtrA2 (Omi) (Human) mAb
Additional Information
Anti-HtrA2 (Omi) (Human) mAb Specifications
| Background: | HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis. |
| Clonality: | Monoclonal |
| Clone Number: | 18-1-83 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 27429 |
| Gene ID Mouse: | 64704 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human 6His tagged HtrA2/Omi |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | HtrA2/Omi |
Applications: IH, IP, WB
| IHC: | 10μg/mL (Heat treatment is necessary for paraffin |
| IPP: | 1μg/200μL of cell extract from 5x106 ce |
| WB: | 1μg/mL |
There are no references for Anti-HtrA2 (Omi) (Human) mAb at this time.
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