Solutions for Life Science & Diagnostics
Anti-DNA Ligase I (Human) mAb
Additional Information
Anti-DNA Ligase I (Human) mAb Specifications
| Background: | DNA ligases are ATP-dependent, nuclear enzymes that catalyze the joining of single and double-strand DNA breaks. Four distinct DNA ligases, designated DNA Ligase I-IV, have been identified in mammalian cells. The 125 kDa DNA Ligase I is a phosphoprotein responsible for joining Okazaki fragments during lagging strand DNA replication. In cooperation with replication factors A and C, DNA polymerase epsilon, and PCNA, it also plays a role in the base and nucleotide excision repair pathways. Deficiencies in DNA Ligase I result in hypersensitivity to DNA-damaging agents and aberrant DNA repair and replication. |
| Clonality: | Monoclonal |
| Clone Number: | 5H5 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH7.2 |
| Gene ID Human: | 3978 |
| Gene ID Mouse: | 16881 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human DNA Ligase I |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Ligase I |
Applications: FCM, IC, IH, IP, WB
| FCM: | 10 ug/mL (final concentration) |
| ICC: | 10 ug/mL |
| IHC: | 10 ug/mL (Heat treatment is necessary for paraffin |
| IPP: | 2 ug/200 uL of cell extract from 5x106 |
| WB: | 0.2 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-DNA Ligase I (Human) mAb at this time.
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