Solutions for Life Science & Diagnostics
Anti-p53 (Human) mAb
Additional Information
Anti-p53 (Human) mAb Specifications
| Background: | The tumor suppressor p53 controls numerous downstream targets that can result in variable outcomes, including apoptosis, transient growth arrest, and sustained growth arrest or senescence. p53 is induced on DNA damage to prevent gene amplification and preserve genetic stability. Induction of G1 arrest is dependent upon sequence-specific DNA binding and transcriptional activation of p53 target genes such as p21WAF-1/CIP-1. p21 is an inhibitor of cyclin dependent kinase (CDK) and blocks the activity of G1 cyclin-CDK complexes. In cells induction of p21 can block phosphorylation and inactivation of the retinoblastoma protein, thus contributing to G1 arrest. p53 functions to eliminate and inhibit the proliferation of abnormal cells, thereby preventing neoplastic development. Abrogation of the negative growth regulatory functions of p53 occurs in many, perhaps all, human tumors. |
| Clonality: | Monoclonal |
| Clone Number: | DO-1 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 7157 |
| Gene ID Mouse: | 22059 |
| Host Species: | Mouse |
| Immunogen: | human p53 N-terminus synthetic peptide (11-25 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | p53 |
Applications: IH, IP, WB
| IHC: | 2 ug/mL (Heat treatment is necessary for paraffin |
| IPP: | 2 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-p53 (Human) mAb at this time.
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