Solutions for Life Science & Diagnostics
Anti-SOCS-1 (Mouse) mAb
Additional Information
Anti-SOCS-1 (Mouse) mAb Specifications
| Background: | The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24 kDa protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also induced by and inhibits the signaling action of IL-3, IL-4, LIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN-ï§ signaling and T cell differentiation. |
| Clonality: | Monoclonal |
| Clone Number: | 4H1 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 8651 |
| Gene ID Mouse: | 12703 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Mouse SOCS-1 (2-78 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | SOCS1 |
Applications: WB
| WB: | 0.1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-SOCS-1 (Mouse) mAb at this time.
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