Solutions for Life Science & Diagnostics
Anti-BUBR1 (Human) mAb
Additional Information
Anti-BUBR1 (Human) mAb Specifications
| Background: | Metaphase checkpoint controls sense abnormalities in chromosome alignment during mitosis and prevent progression to anaphase until proper alignment has been attained. A number of proteins, including Mitotic arrest deficiency protein 2 (MAD2), Budding uninhibited benzimidazole 1 (BUB1) and Budding uninhibited benzimidazole receptor 1 (BUBR1), have been implicated in the metaphase checkpoint control in mammalian cells. BUB1 and BUBR1 both localize to kinetochores during mitosis, suggesting that they play a role in delaying anaphase until all chromosomes achieve correct, bipolar attachment to the spindle. BUB1 and BUBR1 respond differently to spindle dynamics; they are part of a common complex during mitosis and BUB1 and BUBR1 may integrate different 'spindle assembly signals' into a single signal which can then be interpreted by downstream cell cycle regulators. |
| Clonality: | Monoclonal |
| Clone Number: | 8G1 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 701 |
| Gene ID Mouse: | 12236 |
| Host Species: | Mouse |
| Immunogen: | Recombinant fulll length Human BUBR1 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | BUBR1 |
Applications: IC, IP, WB
| ICC: | 2 ug/mL |
| IPP: | 5 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-BUBR1 (Human) mAb at this time.
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