Solutions for Life Science & Diagnostics
Anti-IKKγ (Human) mAb
Additional Information
Anti-IKKγ (Human) mAb Specifications
| Background: | The I-ï«B kinase complex (IKK) functions as a mediator of NF-ï«B activation in response to multIPPle stimuli by phosphorylating I-ï«B inhibitor proteins and causing their degradation. IKK contains two structurally related catalytic subunits termed IKKï¡ and IKKï¢ as well as a noncatalytic subunit called IKKï§/NEMO. IKK is composed of an IKKï§/NEMO homodimer bound together with either an IKKï¡/IKKï¢ heterodimer or an IKKï¢ homodimer Although IKKï§/ NEMO itself does not have kinase activity, it is essential for NF-ï«B activation, most likely via a scaffold function that is required for IKK activity. Mutations in the X-linked gene encoding IKKï§ can interfere with NF-ï«B signaling and lead to immunodeficiency disease. |
| Clonality: | Monoclonal |
| Clone Number: | EA2-6 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 8517 |
| Gene ID Mouse: | 16151 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human IKKgamma (262-319 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | IKKg |
Applications: IH, IP, WB
| IHC: | 10 ug/mL (Heat treatment is necessary for paraffin |
| IPP: | 10 ug/200 uL of cell extract from 5x106 |
| WB: | 0.1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-IKKγ (Human) mAb at this time.
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