Solutions for Life Science & Diagnostics
Anti-Bcl-xL (Human/Mouse) mAb
Additional Information
Anti-Bcl-xL (Human/Mouse) mAb Specifications
| Background: | Bcl-x is a member of the Bcl-2 family of apoptosis-regulating proteins. Human Bcl-x is expressed as two splice variants: a larger 233 a.a. protein, Bcl-xL, which suppresses apoptosis, and the smaller 170 a.a. variant, Bcl-xS, which inhibits the ability of Bcl-2 and Bcl-xL to enhance the survival of cells. Bcl-xL has been shown to inhibit caspase-8 signaling in response to Fas antigen or TNF receptor 1 stimulation. Bcl-xL also has been shown to protect a variety of cell types from apoptotic cell death initiated by withdrawal of growth factors (Epo, GM-CSF, IL2, IL5, IGF-1, EGF, and TGF-α), and it may be essential for the long-term survival of hematopoietic stem cells. Bcl-xL is found primarily in mitochondrial membranes of long-lived post-mitotic cells, such as adult brain. Bcl-xL promotes cell survival via the formation of heterodimers with apoptosis inducers such as Bad, Bax, and Bak, and by regulating the electrical and osmotic homeostasis of mitochondria. Bcl-xL closes the mitochondrial porin channel VDAC and thus regulates the release of cytochrome c during apoptosis. Additionally, Bcl-xL binds directly to cytochrome c and this interaction is inhibited by Bcl-xS. Inactivation of Bcl-xL by caspases destroys the protective protein and simultaneously creates a lethal cleavage product. |
| Clonality: | Monoclonal |
| Clone Number: | 2H12 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 572 |
| Gene ID Mouse: | 12015 |
| Host Species: | Mouse |
| Immunogen: | synthetic peptide, QSNRELVVDFLS, which corresponding to N-terminal peptide (3-14 aa) common to human and murine Bcl-xL |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | hBcl-xL |
Applications: WB
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Bcl-xL (Human/Mouse) mAb at this time.
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