Solutions for Life Science & Diagnostics
Anti-Cyclin B1 (Human) mAb
Additional Information
Anti-Cyclin B1 (Human) mAb Specifications
| Background: | Cyclins are evolutionarily conserved regulatory proteins that are essential for controlling the progression of the cell-cycle. Proliferating cells express both cyclin B1 and cyclin B2; expression is normally low in G0/G1, increases in S, and is maximal during the G2/M phase of cell division. Cyclin B1 can be found both on intracellular membranes and free in the cytoplasm, in contrast to cyclin B2, which is membrane-associated. Cyclin B1 binds to p34Cdc2, also known as Cdk1, a cyclin-dependent kinase, to form an inactive complex that accumulates in the cytoplasm. Dephosphorylation by Cdc25 results in activation of the complex and translocation to the nucleus. Cyclin B1 is rapidly degraded at the end of mitosis, and this degradation is essential for cells to exit from mitosis. |
| Clonality: | Monoclonal |
| Clone Number: | V152 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 891 |
| Gene ID Mouse: | 268697 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human Cyclin B1 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat, Hamster |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Cyclin B1 |
Applications: IC, IH, WB
| ICC: | 10 ug/mL |
| IHC: | 1 ug/mL (Heat treatment is necessary for paraffin |
| WB: | 0.1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Cyclin B1 (Human) mAb at this time.
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