Anti-CAF-1 p150 (Human) mAb
Anti-CAF-1 p150 (Human) mAb Specifications
|Background:||Chromatin assembly factor-1 (CAF-1) is a highly conserved member of the histone chaperone family that promotes chromatin assembly during DNA replication in eukaryotes. CAF-1 acts as a specialized assembly factor to target newly synthesized histones to replicating DNA. CAF-1 consists of a complex of three subunits of 150 kDa (p150), 60 kDa (p60), and 48 kDa (p48). The p150 subunit, involved in interaction with histones H3 and H4, is critical to the CAF-1 nucleosome assembly activity and also interacts directly with PCNA (Proliferating Cell Nuclear Antigen) and the methyl-CpG binding protein, MBD1. CAF-1 may also play a regulatory role in DNA damage processing and checkpoint control.
|Formulation:||1.0 mg/mL in PBS/50% glycerol, pH7.2|
|Gene ID Human:||10036|
|Gene ID Mouse:||27221|
|Immunogen:||Human CAF-1 highly purified from human 293 cell nuclei|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: IC, IH, WB
|IHC:||5 ug/mL (Heat treatment is necessary for paraffin |
|WB:||1 ug/mL (for chemiluminescence detection system)|
There are no references for Anti-CAF-1 p150 (Human) mAb at this time.