Solutions for Life Science & Diagnostics
Anti-γ-Catenin (Plakoglobin) mAb
Additional Information
Anti-γ-Catenin (Plakoglobin) mAb Specifications
| Background: | gamma-Catenin, also known as plakoglobin is highly homologous to ï¢-catenin that interacts with cadherins to mediate cell-cell adhesion and associates with LEF/TCF family to regulate the expression of genes that are involved in cell fate determination and cell proliferation. The role of ï§-catenin differs from that of ï¢-catenin. ï¢-Catenin has been implicated in potentiating hyperproliferation and tumor formation, where it has been suggested that ï§-catenin can suppress tumorigenicity. Over expression of ï§-catenin has been shown to suppress cell proliferation and cell tumorigenicity in experimental animals. Also, reduced ï§-catenin expression has been reported in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas. |
| Clonality: | Monoclonal |
| Clone Number: | 15F11 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 3728 |
| Gene ID Mouse: | 16480 |
| Host Species: | Mouse |
| Immunogen: | fusion protein of maltose binding protein conjugated with chicken γ-catenin, N-terminal. |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | γ-catenin |
Applications: IH, IP, WB
| IHC: | 10 μg/mL (Heat treatment is necessary for paraffin |
| IPP: | 2 μg/200-300 μL of cell extract |
| WB: | 1 μg/mL |
There are no references for Anti-γ-Catenin (Plakoglobin) mAb at this time.
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