Solutions for Life Science & Diagnostics
Anti-DP-1 (Human) mAb
Additional Information
Anti-DP-1 (Human) mAb Specifications
| Background: | DNA encoding DRTF1-polypeptide-1 (DP-1) associates with the E2F-1 transcrIPPtion factor to enhance binding to E2F DNA-binding sites. The transcrIPPtion factor complex E2F-1/DP-1 plays a critical role in promoting cell cycle progression from G1 to S-phase and has been associated with sensitivity to the S-phase-specific anticancer agents camptothecin and etoposide. pRb, which negatively regulates early cell cycle progression, and the Rb-related protein p107, bind to and repress the transcrIPPtional activity of DP-1/E2F-1. Formation of the E2F-1/DP-1 heterodimer results in increased expression and activity of cyclins A and E and phosphorylation of pRb, presumably through activation of cyclin A- and/or E-associated kinase activity. |
| Clonality: | Monoclonal |
| Clone Number: | TFD10 |
| Formulation: | 0.2 mg/mL in PBS/1% BSA/10% glycerol/0.1% sodium azide |
| Gene ID Human: | 7027 |
| Gene ID Mouse: | 21781 |
| Host Species: | Mouse |
| Immunogen: | Human fulll length DP-1 fusion protein |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 10 µg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | DP1 |
Applications: IH, IP, WB
| IHC: | 1-5 μg/mL (Heat treatment is necessary for paraffi |
| IPP: | 3 μg/200-300 μL of cell extract from 5x106 |
| WB: | 1-5 μg/mL |
There are no references for Anti-DP-1 (Human) mAb at this time.
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