Solutions for Life Science & Diagnostics
Anti-Chk2 (Human) mAb
Additional Information
Anti-Chk2 (Human) mAb Specifications
| Background: | Checkpoint kinase 2 (Chk2), also known as Cds1, is a 61 kDa nuclear protein that functions as a checkpoint kinase to regulate the cell cycle progression following DNA damage. Chk2 inhibits CDC2 by inactivating CDC25, the phosphatase that normally activates CDC2. Other targets for Chk2 include the tumor suppressors BRCA1 and p53, which it stabilizes by phosphorylation of Ser20. Chk2 is itself phosphorylated and activated by ATM following DNA damage. Defects in Chk2 contribute to the development of human cancers, and implicate Chk2 as a candidate tumor suppressor and an attractive target for drug discovery. |
| Clonality: | Monoclonal |
| Clone Number: | DCS-273 |
| Formulation: | 0.2 mg/mL in PBS/1% BSA/10% glycerol/0.09% sodium azide |
| Gene ID Human: | 11200 |
| Gene ID Mouse: | 50883 |
| Host Species: | Mouse |
| Immunogen: | Human fulll length Chk2 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 10 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | Chk2 |
Applications: IH, IP, WB
| IHC: | 1-5 ug/mL (Heat treatment is necessary for paraffi |
| IPP: | 3 ug/200-300 uL of cell extract |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Chk2 (Human) mAb at this time.
