Solutions for Life Science & Diagnostics

Anti-Chk2 (Human) mAb

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SKUNameSizeQtyPriceAdd to Cart
K0088-3S Anti-Chk2 (Human) mAb 10 µg $99.50

Additional Information

Anti-Chk2 (Human) mAb Specifications

Background:Checkpoint kinase 2 (Chk2), also known as Cds1, is a 61 kDa nuclear protein that functions as a checkpoint kinase to regulate the cell cycle progression following DNA damage. Chk2 inhibits CDC2 by inactivating CDC25, the phosphatase that normally activates CDC2. Other targets for Chk2 include the tumor suppressors BRCA1 and p53, which it stabilizes by phosphorylation of Ser20. Chk2 is itself phosphorylated and activated by ATM following DNA damage. Defects in Chk2 contribute to the development of human cancers, and implicate Chk2 as a candidate tumor suppressor and an attractive target for drug discovery.
Clonality:Monoclonal
Clone Number:DCS-273
Formulation:0.2 mg/mL in PBS/1% BSA/10% glycerol/0.09% sodium azide
Gene ID Human:11200
Gene ID Mouse:50883
Host Species:Mouse
Immunogen:Human fulll length Chk2
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Isotype:IgG2a
Product Type:Primary Antibody
Shipping:4
Size:10 µg
Species Reactivities:Human
Status:RUO
Storage:4℃
Target:Chk2

Applications: IH, IP, WB

IHC:1-5 ug/mL (Heat treatment is necessary for paraffi
IPP:3 ug/200-300 uL of cell extract
WB:1 ug/mL (for chemiluminescence detection system)

There are no references for Anti-Chk2 (Human) mAb at this time.