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Product Catalog |
Chk2 Monoclonal Antibody : Trial SizeCode No: K0088-3S
Target:
Chk2 (DCS-273) Background:
Checkpoint kinase 2 (Chk2), also known as Cds1, is a 61 kDa nuclear protein that functions as a checkpoint kinase to regulate the cell cycle progression following DNA damage. Chk2 inhibits CDC2 by inactivating CDC25, the phosphatase that normally activates CDC2. Other targets for Chk2 include the tumor suppressors BRCA1 and p53, which it stabilizes by phosphorylation of Ser20. Chk2 is itself phosphorylated and activated by ATM following DNA damage. Defects in Chk2 contribute to the development of human cancers, and implicate Chk2 as a candidate tumor suppressor and an attractive target for drug discovery.
Size:
10 µg
Application:
WB
Application:
IPP
Application:
IHC
Clone Number:
DCS-273
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Isotype:
IgG2a
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Syljuäsen, R.G., et al., Cancer Res. 66, 10253-10257 (2006) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Reactivity:
This antibody reacts with human Chk2 on Western blotting, ImmunoprecIPPitation and Immunohistochemistry. The DCS-273 epitope resides in the putative protein-protein interaction FHA domain of human Chk2 Ref. 5).
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
