Solutions for Life Science & Diagnostics
Anti-p57Kip2 (Human) mAb
Additional Information
Anti-p57Kip2 (Human) mAb Specifications
| Background: | p57/KIPP-2 (also known as CDKN 1C) is a potent inhibitor of several G1 cyclin/CDK2 complexes, and is a negative regulator of cell proliferation. It is closely-related to other cyclin dependent kinase inhibitors such as p21 (CIPP1) and p27 (KIPP-1), as they share a common N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. However, unlike KIPP-1, KIPP-2 is not regulated by p53. KIPP-2 is involved in decisions to exit the cell cycle during development and differentiation, and overexpression of KIPP-2 arrests cells in G1. The gene encoding human KIPP 2 is located on chromosome 11p15.5, a region implicated in two sporadic cancers, Wilm's tumor and Beckwith Wiedemann syndrome (BWS, a cancer syndrome), making it a tumor suppressor candidate. |
| Clonality: | Monoclonal |
| Clone Number: | DCS-230 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 1027 |
| Gene ID Mouse: | 12576 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human p57Kip2 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | P57Kip1 |
Applications: WB
| WB: | 10 ug/mL |
There are no references for Anti-p57Kip2 (Human) mAb at this time.
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