Solutions for Life Science & Diagnostics
Anti-CDC25C (Human) mAb
Additional Information
Anti-CDC25C (Human) mAb Specifications
| Background: | The activity of cyclin-dependent kinases is regulated by their phosphorylation status, which is controlled by the antagonistic action of CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25C is a ~56 kDa dual specific protein phosphatase that controls entry into mitosis by regulating the dephosphorylation of the Cdk1/cyclin B complex. Phosphorylation of Cdc25C creates a binding site for 14-3-3 protein which inhibits Cdc25C. This prevents activation of the Cdk1/cyclin B complex and prevents mitotic entry. Cdc25C is phosphorylated by checkpoint kinases throughout interphase but becomes dephosphorylated during mitosis. Cdc25C is also regulated by p53 via a p53 response element in its promoter, and it is predominantly expressed in the G2 phase of the cell cycle. |
| Clonality: | Monoclonal |
| Clone Number: | DCS-193 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 995 |
| Gene ID Mouse: | 12532 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human CDC25C |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | CDC25C |
Applications: WB
| WB: | 10 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-CDC25C (Human) mAb at this time.
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