Solutions for Life Science & Diagnostics
Anti-CDC25A (Human) mAb
Additional Information
Anti-CDC25A (Human) mAb Specifications
| Background: | The members of the CDC25 family, CDC25A, CDC25B, and CDC25C, activate the cyclin-dependent kinases at different points in the cell cycle by dephosphorylating key proteins. The ~65 kDa CDC25A protein is a tyrosine phosphatase that regulates the G1/S transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes, which are required for DNA synthesis. CDC25A acts as a checkpoint to prevent DNA replication following DNA damage. DNA damage induces phosphorylation of CDC25A, resulting in its rapid degradation via the ubiquitin-proteosome pathway, and thus silencing Cdk2 activity. |
| Clonality: | Monoclonal |
| Clone Number: | DCS-124 |
| Formulation: | 0.2 mg/mL in PBS/1% BSA/10% glycerol/0.09% sodium azide |
| Gene ID Human: | 993 |
| Gene ID Mouse: | 12530 |
| Host Species: | Mouse |
| Immunogen: | Human fulll length CDC25A |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 10 µg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | CDC25A |
Applications: IP, WB
| IPP: | 3 ug/200-300 uL of cell extract |
| WB: | 5 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-CDC25A (Human) mAb at this time.
