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CDC25A(DCS-124) Monoclonal Antibody

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Code No: K0073-3
Datasheet: 
application/pdf iconK0073-3.pdf
FID:5324 | PATH:sites/default/files/datasheets/K0073-3.PDF
Target: 

CDC25A (DCS-124)

Background: 

The members of the CDC25 family, CDC25A, CDC25B, and CDC25C, activate the cyclin-dependent kinases at different points in the cell cycle by dephosphorylating key proteins. The ~65 kDa CDC25A protein is a tyrosine phosphatase that regulates the G1/S transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes, which are required for DNA synthesis. CDC25A acts as a checkpoint to prevent DNA replication following DNA damage. DNA damage induces phosphorylation of CDC25A, resulting in its rapid degradation via the ubiquitin-proteosome pathway, and thus silencing Cdk2 activity.

Size: 
100 μg
Application: 
WB
Application: 
IPP
Clone Number: 
DCS-124
Concentration: 
1 mg/mL
Product Type: 
Primary Antibody
Host Species: 
Mouse
Species Reactivities: 
Human
Species Reactivities: 
Mouse
Species Reactivities: 
Rat
Isotype: 
IgG2a
Storage Temp. (°C): 
-20
Shipping Temp. (°C): 
4
Pictures: 
CDC25A(DCS-124) Monoclonal Antibody
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References: 

1) Mailand, N., et al. Science 288, 1425-1429 (2000)
2) Mailand, N., et al. EMBO J. 21, 5911-5920 (2002)

Formulation: 
100 g IgG in 100 L volume of PBS containing 50% glycerol, pH 7.2. Contains no preservatives.
Reactivity: 
This antibody reacts with human, mouse and rat CDC25A.
Intended Use: 
For Research use only. Not for use in diagnostic procedure.
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