CDC25A(DCS-120) Monoclonal Antibody

Datasheet:

Target:

CDC25A (DCS-120)

Background:

The members of the CDC25 family, CDC25A, CDC25B, and CDC25C, activate the cyclin-dependent kinases at different points in the cell cycle by dephosphorylating key proteins. The ~65 kDa CDC25A protein is a tyrosine phosphatase that regulates the G1/S transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes, which are required for DNA synthesis. CDC25A acts as a checkpoint to prevent DNA replication following DNA damage. DNA damage induces phosphorylation of CDC25A, resulting in its rapid degradation via the ubiquitin-proteosome pathway, and thus silencing Cdk2 activity.

Size:

100 μg

Application:

WB

Application:

IPP

Clone Number:

DCS-120

Concentration:

1 mg/mL

Product Type:

Primary Antibody

Host Species:

Mouse

Species Reactivities:

Human

Species Reactivities:

Mouse

Species Reactivities:

Rat

Isotype:

IgG2a

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

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Formulation:

100 g IgG in 100 L PBS containing 50% glycerol, pH 7.2. Contains no preservatives.

Reactivity:

This antibody reacts with human, mouse and rat CDC25A.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

Product Catalog

CDC25A(DCS-120) Monoclonal Antibody

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