Angiogenesis
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Product Catalog |
CDC7 Monoclonal Antibody : Trial SizeCode No: K0070-3S
Target:
CDC7 Background:
Cell division cycle-7 (CDC7) was initially discovered as a temperature sensitive cell cycle mutant in Saccharomyces cerevisiae. CDC7 is required in the mitotic cell cycle for the initiation of DNA synthesis. CDC7 forms a complex with a Dbf4-related regulatory subunit to generate an active Ser/Thr kinase that functions in DNA replication, repair, and mitotic recombination. CDC7-Dbf4 efficiently phosphorylates several proteins that are required for the initiation of DNA replication, including five of the six minichromosome maintenance (MCM) proteins and the p180 subunit of DNA polymerase -primase. CDC7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. A human homolog of the yeast CDC7 is over-expressed in some tumors and transformed cell lines.
Size:
10 µg
Application:
WB
Application:
IPP
Application:
IHC
Clone Number:
DCS-342
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Isotype:
IgG2b
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Kim. B. J., et al., J. Biol. Chem. 282, 30029-30038 (2007) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Reactivity:
This antibody reacts with human CDC7 on Western blotting, ImmunoprecIPPitation and Immunohistochemistry.
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
