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CDK7 Monoclonal Antibody

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Code No: K0068-3
Datasheet: 
application/pdf iconK0068-3_ver4.pdf
FID:8934 | PATH:sites/default/files/datasheets/K0068-3_ver4.pdf
Target: 

Cdk7

Background: 

Cyclin-dependent kinase 7 (Cdk7) functions in two essential cellular processes: transcrIPPtion and cell cycle regulation. The 40-42 kDa Cdk7 is the catalytic subunit of the Cdk-activating kinase (CAK), the enzyme responsible for phosphorylating and activating many Cdks controlling cell cycle progression, including Cdc2 and Cdk2. Additionally, Cdk7 and its partner Cyclin H are involved in transcrIPPtional regulation, since Cdk7 is the kinase subunit of the general transcrIPPtion factor TFIIH that phosphorylates the C-terminal domain of RNA polymerase II. Hence, Cdk7 may provide a link between cell-cycle control and transcrIPPtional regulation.

Size: 
100 μg
Application: 
WB
Application: 
IPP
Application: 
IHC
Clone Number: 
MO-1
Concentration: 
1 mg/mL
Product Type: 
Primary Antibody
Host Species: 
Mouse
Species Reactivities: 
Human
Species Reactivities: 
Rat
Isotype: 
IgG2b
Storage Temp. (°C): 
-20
Shipping Temp. (°C): 
4
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References: 

1) Syljuåsen, R. G., et al., Cancer Res. 66, 10253-10257 (2006)
2) Syljuåsen, R. G., et al., Mol. Cell. Biol. 25, 3553-3562 (2005)
3) Coulonval, K., et al., J. Biol. Chem. 278, 52052-52060 (2003)
4) Sørensen, C. S., et al., Cancer Cell 3, 247-258 (2003)
5) Araujo, S. J., et al., Mol. Cell Biol. 21, 2281-2291 (2001)
6) Sørensen, C. S., et al., Mol. Cell Biol. 21, 3692-3703 (2001)
7) Jensen, S. S., et al., Mol. Endocrinol. 15, 1370-1380 (2001)
8) OssIPPow, V., et al., Mol. Cell. Biol. 19, 1242-1250 (1999)
9) Tassan, J. P., et al., J. Cell Biol. 127, 467-478 (1994)

Formulation: 
100 g IgG in 100 L volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Reactivity: 
This antibody reacts with human and rat Cdk7 on Western blotting, ImmunoprecIPPitation and Immunohistochemistry.
Intended Use: 
For Research use only. Not for use in diagnostic procedure.
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