CDK6 Monoclonal Antibody

Datasheet:

Target:

Cdk6 (DCS-83)

Background:

Cdk6 (Cyclin-dependent kinase-6) is a 38-40 kDa member of the Cdk family of mitotic kinases involved in cell cycle progression. The Cdk6 phosphoprotein, like Cdk4, associates with D-cyclins to regulate cell proliferation. Following translocation to the nucleus, the Cdk6 is phosphorylated by CAK, and the Cdk6 complex, in association with PCNA, phosphorylates the retinoblastoma (Rb) protein. Overexpression of Cdk6 has been associated with several different types of cancer.

Size:

100 μg

Application:

WB

Application:

IPP

Clone Number:

DCS-83

Concentration:

1 mg/mL

Product Type:

Primary Antibody

Host Species:

Mouse

Species Reactivities:

Human

Species Reactivities:

Mouse

Species Reactivities:

Rat

Isotype:

IgG1

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

Related Products:

K0062-3 Anti-Cyclin D1 (DCS-6) available soon
MD-17-3 Anti-Cyclin D1 (5D4)
K0063-3 Anti-Cyclin D2 (DCS-3)
K0064-3 Anti-Cyclin D2 (DCS-5) available soon
K0013-3 Anti-Cyclin D3 (DCS-22)
MT-19-3 Anti-Cdc2Hs (5F6)
MK-13-3 Anti-Cdk2 (8A12)
K0065-3 Anti-Cdk4 (DCS-156)
K0067-3 Anti-Cdk6 (DCS-130) available soon
K0068-3 Anti-Cdk7 (DCS-MO1)
RELATED PRODUCTS(continued):
K0077-3 Anti-p16INK4a (DCS-50) available soon
K0078-3 Anti-p15INK4b (DCS-114) available soon
K0079-3 Anti-p18INK4c (DCS-118) available soon
K0080-3 Anti-p19INK4d (DCS-100) available soon
K0081-3 Anti-p21WAF-1/CIPP1 (DCS-60) available soon
MK-15-1 Anti-RB (3H9)
M045-3 Anti-phospho RB (2C4)

References:

1) Lukas, C., et al. Hybridoma 18, 225-234 (1999)
2) Tsubari, M., et al. Mol. Cell. Biol. 19, 3654-3663 (1999)

Formulation:

100 g IgG in 100 L volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Reactivity:

This antibody reacts with human, mouse and rat Cdk6.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

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