Anti-FHL2 (Human) mAb
Anti-FHL2 (Human) mAb Specifications
|Alternative Names:||four and a half LIM domains 2|
|Background:||Proteins containing LIM domains (which are double zinc finger motifs implicated in protein binding) are important regulators of cell growth, cell differentiation, and remodeling of the cell cytoskeleton. Human Four-and-a-half LIM-only protein 2 (FHL2), also known as DRAL/Slim3 is a 32 kDa protein expressed predominantly in human heart and to a lesser extent in skeletal muscle, testis, and prostate epithelium. Since FHL2 is abundant in heart tissue, it may play a role in the regulation of myofibrillogenesis of heart via LIM-domain binding to focal adhesions. FHL2 has also been identified as a co-activator of the androgen receptor where it promotes androgen receptor transcriptional activity. Stimulation of the Rho signaling pathway induces translocation of FHL2 to the nucleus and subsequent activation of FHL2- and androgen receptor-dependent genes. FHL2 also acts as a trancriptional repressor in muscle cells and is involved in modulation of Î²-catenin-dependent transcription of Wnt-responsive genes.
|Formulation:||1.0 mg/mL in PBS/50% glycerol, pH 7.2|
|Gene ID Human:||2274|
|Gene ID Mouse:||14200|
|Immunogen:||Recombinant Human fulll length FHL2|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||Human, Mouse|
Applications: IH, IP, WB
|IHC:||1-5 ug/mL (Heat treatment is necessary for paraffi|
|IPP:||3 ug/200-300 uL of cell extract|
|WB:||1-5 ug/mL (for chemiluminescence detection system)|
There are no references for Anti-FHL2 (Human) mAb at this time.