Solutions for Life Science & Diagnostics
Anti-FHL2 (Human) mAb
Additional Information
Anti-FHL2 (Human) mAb Specifications
| Alternative Names: | four and a half LIM domains 2 |
| Background: | Proteins containing LIM domains (which are double zinc finger motifs implicated in protein binding) are important regulators of cell growth, cell differentiation, and remodeling of the cell cytoskeleton. Human Four-and-a-half LIM-only protein 2 (FHL2), also known as DRAL/Slim3 is a 32 kDa protein expressed predominantly in human heart and to a lesser extent in skeletal muscle, testis, and prostate epithelium. Since FHL2 is abundant in heart tissue, it may play a role in the regulation of myofibrillogenesis of heart via LIM-domain binding to focal adhesions. FHL2 has also been identified as a co-activator of the androgen receptor where it promotes androgen receptor transcriptional activity. Stimulation of the Rho signaling pathway induces translocation of FHL2 to the nucleus and subsequent activation of FHL2- and androgen receptor-dependent genes. FHL2 also acts as a trancriptional repressor in muscle cells and is involved in modulation of β-catenin-dependent transcription of Wnt-responsive genes. |
| Clonality: | Monoclonal |
| Clone Number: | 11-134 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 2274 |
| Gene ID Mouse: | 14200 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Human fulll length FHL2 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | FHL2 |
Applications: IH, IP, WB
| IHC: | 1-5 ug/mL (Heat treatment is necessary for paraffi |
| IPP: | 3 ug/200-300 uL of cell extract |
| WB: | 1-5 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-FHL2 (Human) mAb at this time.
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