Solutions for Life Science & Diagnostics
Anti-Kaiso mAb
Additional Information
Anti-Kaiso mAb Specifications
| Background: | Kaiso is a member of the POZ-zinc finger family of transcription factors implicated in development and cancer. It acts as a DNA methylation-dependent transcriptional repressor. Kaiso is a dual specificity DNA-binding protein that recognizes the specific consensus sequence CTGCNA as well as methyl-CpG dinucleotides. Two copies of the Kaiso-binding site are present in the matrilysin promoter, implicating matrilysin as a candidate target gene for Kaiso. Kaiso also associates with the adhesion molecule p120ctn and may be a downstream effector of cadherin and/or p120ctn signaling. The DNA-binding ability of Kaiso with either recognition site was inhibited by p120ctn. Thus, Kaiso may link events at the cell surface with DNA methylation-dependent gene silencing. |
| Clonality: | Monoclonal |
| Clone Number: | 11D7 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 10009 |
| Gene ID Mouse: | 56805 |
| Host Species: | Mouse |
| Immunogen: | Kaiso antigen corresponding to 1-499 aa |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Kaiso |
Applications: IP, WB
| IPP: | 2 μg/200-300 μL of cell extract |
| WB: | 5 μg/mL |
There are no references for Anti-Kaiso mAb at this time.
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