- Diagnostic Products
- Research Products
|Background:||CD74 was originally identified as the major histocompatibility complex (MHC) class II-associated invariant chain (Ii). CD74 is a 35 kDa protein expressed on the nuclear membrane and in the cytoplasm of B lymphocytes and antigen presenting cells (APCs). CD74 has been thought traditionally to only play a role intracellularly in regulating the transport and functions of class II MHC molecules. Cell-surface form of CD74 is modified by the addition of chondroitin sulfate and associated with class II on the surface of APCs. Macrophage migration inhibitory factor (MIF), an important regulator of innate and acquired immune responses, has been shown to bind to cell-surface CD74 and initiate the MAPK activation. Activation of cell-surface CD74 initiates a signaling cascade resulting in NF-ï«B activation and leading to proliferation and survival. In addition, many studies have demonstrated CD74 expression in various cancers, including bladder, gastric, renal, non-small-cell lung, thymic epithelial neoplasms, and certain types of sarcoma. CD74 expression in many of these cancers has been suggested to serve as a prognostic factor, with higher relative expression of CD74 behaving as a marker of tumor progression.|
|Gene ID Human:||972|
|Gene ID Mouse:||16149|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for CD74 Monoclonal Antibody at this time.