- Diagnostic Products
- Research Products
|Background:||The JNK (c-Jun N-terminal Kinase) pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-ï¡ and IL-1), UV light, inhibitors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4), which in turn activates SAPK (stress-activated protein kinase, also known as JNK). JNK binds tightly to the N-terminal region of c-Jun and ATF-2, and phosphorylates c-Jun at Ser63 and Ser73 and ATF-2 at Thr69 and Thr71.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, IP, IH
There are no references for JNK Polyclonal Antibody at this time.