GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is one of the key enzymes involved in glycolysis.1-2 It catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Besides functioning as a glycolytic enzyme in cytoplasm, recent evidence suggest that mammalian GAPDH is also involved in a great number of intracellular processes such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. GAPDH has also been implicated in cancer progression3, programmed neuronal cell death, and age-related neuronal diseases such as Alzheimer's and Huntington's. GADPH is widely expressed and can also serve as a loading control.