- Diagnostic Products
- Research Products
|Background:||Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1â€“4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factorâ€“ and vascular endothelial growth factorâ€“induced proliferation and differentiation by repressing pathways leading to MAP kinase activation.1 Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts.2 A recent study shows that Sprouty-1 and â€“2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.2|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Sprouty-1 Polyclonal Antibody at this time.