Solutions for Life Science & Diagnostics
Sprouty-1 Polyclonal Antibody
Additional Information
Sprouty-1 Polyclonal Antibody Specifications
| Background: | Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1–4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor– and vascular endothelial growth factor–induced proliferation and differentiation by repressing pathways leading to MAP kinase activation.1 Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts.2 A recent study shows that Sprouty-1 and –2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.2 |
| Clonality: | Polyclonal |
| Host Species: | rabbit |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 ug |
| Species Reactivities: | M |
| Status: | RUO |
| Storage: | -20 |
| Target: | Sprouty-1 |
Applications: WB
There are no references for Sprouty-1 Polyclonal Antibody at this time.
