GSK3beta Monoclonal Antibody
GSK3beta Monoclonal Antibody Specifications
|Background:||GSK3 (glycogen synthase kinase-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase.1 The two isoforms (GSK3Î± and GSK3Î²) of this protein show a high degree of amino acid homology. GSK3Î² is involved in energy metabolism, neuronal cell development, and body pattern formation.2 GSK3Î² participates in the WNT signaling pathway, and it has been implicated in the hormonal control of several regulatory proteins, including glycogen synthase, myb, and the transcription factor Jun. GSK3Î² has also been linked to neurodegenerative disease. It is known to hyperphosphorylate tau in intact cells on all residues investigated with phospho-tau antibodies3, a mechanism implicated in paired helical filament formation in Alzheimerâ€™s disease. Evidence also suggests that phosphorylation of GSK3Î² on Tyr216 is an important mechanism by which cellular insults can lead to neuronal death.
|Host Species:||mouse |
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M, R|
There are no references for GSK3beta Monoclonal Antibody at this time.