Solutions for Life Science & Diagnostics
GSK3beta Monoclonal Antibody
Additional Information
GSK3beta Monoclonal Antibody Specifications
| Background: | GSK3 (glycogen synthase kinase-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase.1 The two isoforms (GSK3α and GSK3β) of this protein show a high degree of amino acid homology. GSK3β is involved in energy metabolism, neuronal cell development, and body pattern formation.2 GSK3β participates in the WNT signaling pathway, and it has been implicated in the hormonal control of several regulatory proteins, including glycogen synthase, myb, and the transcription factor Jun. GSK3β has also been linked to neurodegenerative disease. It is known to hyperphosphorylate tau in intact cells on all residues investigated with phospho-tau antibodies3, a mechanism implicated in paired helical filament formation in Alzheimer’s disease. Evidence also suggests that phosphorylation of GSK3β on Tyr216 is an important mechanism by which cellular insults can lead to neuronal death. |
| Clonality: | Monoclonal |
| Clone Number: | ZG004 |
| Host Species: | mouse |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 ug |
| Species Reactivities: | H, M, R |
| Status: | RUO |
| Storage: | -20 |
| Target: | GSK3beta |
Applications: WB, ELISA
There are no references for GSK3beta Monoclonal Antibody at this time.
