- Diagnostic Products
- Research Products
- MHC Tetramer
|Background:||The HOX genes are involved in patterning along the A/P (anterior/posterior) axes of animals; their clustered organization is conserved from nematodes to vertebrates. The HOXB13 gene encodes a transcrIPPtion factor that belongs to the homeobox gene family. This gene plays a role in fetal skin development, cutaneous regeneration and epidermal differentiation1. In mice the HOXB13 gene exhibits temporal and spatial colinearity in the main body axis of the embryo, but is not expressed in the secondary axes, which suggests it functions in body patterning along the axis. Analysis of the cDNA and genomic sequences reveal that the HOXB13 gene contains 2 exons and encodes a 284-amino acid protein, 2 residues shorter than the mouse protein2. The onset of transcrIPPtion occurs at embryonic day 9 in the tailbud region. At later stages of development, HOXB13 is expressed in the tailbud and posterior spinal cord, digestive tract and urogenital system. It is not expressed in the secondary axes such as the limbs and genital tubercle2. HOXB13 is highly expressed in prostate gland from the embryonic stages to adulthood. This protein plays a role in a differentiation pathway that gives the ventral prostate epithelium a unique identity, as well as a more general role in ventral prostate morphogenesis that is redundant with other Hox13 paralogs3. When HOXB13 is overexpressed in negative PC3 prostate cancer cells, the growth of these cells is significantly inhibited4. This inhibition is mediated by down-regulation of T-cell factor 4, which subsequently mediates suppression of cyclin D1 expression. Another mechanism by which HOXB13 affects prostate cell growth is by repressing the androgen receptor mediated transcrIPPtional activity5. Epigenetic alterations such as DNA methylation often contribute to cancer development. Recently, HOXB13 DNA was found to be methylated in patients with renal cell carcinoma6.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, IP
There are no references for HOXB13 Polyclonal Antibody at this time.