- Diagnostic Products
- Research Products
|Background:||Heyl is a member of the Hairy/ Enhancer of split (E(spl))-related with YRPW motif (Hey) genes, which are a subfamily of mammalian (E(spl))-related basic helix-loop-helix (bHLH) genes that encode a carboxy-terminal KPYRPWG sequence3. The proteins are also known as hairy-related transcrIPPtion factors (HRT). Three hairy-related bHLH transcrIPPtion factor genes were isolated and characterized from mouse and human (HEY1, HEY2 and HEYL). All three HEY genes have a similar genomic structure with five exons7. While the overall structure with the bHLH domain, orange domain and WRPW motif is similar, the last motif is absent in HEYL7. HEYL (HRT3) maps to human chromosome 1p34.37. Hey genes are important transmitters for signals that shape the cardiovascular system during development and possibly in later life1. HEY (HRT) proteins may regulate specific set of cardiac genes by modulating the function of GATA proteins and other cardiac transcrIPPtional activators in a signal-dependent manner4. HEYL is strongly expressed in the presomitic mesoderm, the somites, the perIPPheral nervous system and the smooth muscle of the arteries4. HEYL expression overlaps with Notch3 expression in vascular smooth muscle cells and thymus4. Loss of HEYL expression at the level of nascent somites in Notch1 and Delta-Like1 knockout mutants implicates HEYL as a Notch effector during somite formation4. HRT genes are downstream targets for Notch signaling and are part of a negative autoregulatory loop whereby HRT proteins repress their own expression though interference with Notch signaling4. Invasive breast cancer vasculature induces a high expression level of specific transcrIPPtion factors, including HEYL that may drive gene expression changes necessary for breast cancer neovascularization6. HEYL is expressed in tumor endothelial cells and is able to both induce proliferation and attenuate programmed cell death of primary endothelial cells in vitro 6.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, R|
Applications: WB, IF
There are no references for HEYL (Hairy/enhancer-of-split related with YRPW motif-like) Polyclonal Antibody at this time.