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IGF1R beta   Monoclonal Antibody

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SKUNameSizeQtyPriceAdd to Cart
EP-2058 IGF1R beta   Monoclonal Antibody 100 ug $351.75

Additional Information

IGF1R beta   Monoclonal Antibody Specifications

Background:Insulin-like growth factor 1 receptor (IGF1R, CD221, JTK13) binds insulin-like growth factor 1 (IGF1) with high affinity. IGF1 is produced in numerous tissues, particularly the liver, in response to growth hormone stimulation and is an important factor in the regulation of post-natal growth and development.1 IGF1R plays a critical role in transformation events, and cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.2 Transgenic mice over-expressing IGF1R in the heart display cardiac hypertrophy which is characteristic of physiological hypertrophy (i.e. normal organization of cardiac structure and normal or enhanced cardiac function) as opposed to pathological hypertrophy (i.e. altered pattern of gene expression, fibrosis, cardiac dysfunction, and increased morbidity and mortality). Current evidence indicates that physiological hypertrophy involves the IGF1-PI3K (p110) pathway whereas pathological hypertrophy utilizes the Gq-pathway.3
Clonality:Monoclonal
Clone Number:ZI001
Host Species:mouse
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Isotype:IgG1 k
Product Type:Primary Antibody
Shipping:4
Size:100 ug
Species Reactivities:H
Status:RUO
Storage:-20
Target:IGF1R beta  

Applications: WB, ELISA, IH

There are no references for IGF1R beta   Monoclonal Antibody at this time.