- Diagnostic Products
- Research Products
|Background:||Insulin-like growth factor 1 receptor (IGF1R, CD221, JTK13) binds insulin-like growth factor 1 (IGF1) with high affinity. IGF1 is produced in numerous tissues, particularly the liver, in response to growth hormone stimulation and is an important factor in the regulation of post-natal growth and development.1 IGF1R plays a critical role in transformation events, and cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.2 Transgenic mice over-expressing IGF1R in the heart display cardiac hypertrophy which is characteristic of physiological hypertrophy (i.e. normal organization of cardiac structure and normal or enhanced cardiac function) as opposed to pathological hypertrophy (i.e. altered pattern of gene expression, fibrosis, cardiac dysfunction, and increased morbidity and mortality). Current evidence indicates that physiological hypertrophy involves the IGF1-PI3K (p110) pathway whereas pathological hypertrophy utilizes the Gq-pathway.3|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, ELISA, IH
There are no references for IGF1R beta Monoclonal Antibody at this time.