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CD61-Alexa Fluor®647

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Code No: D281-A64
Datasheet: 
application/pdf iconD281-A64_anti-CD61(T74)-A647_ver.1.1.pdf
FID:12028 | PATH:sites/default/files/datasheets/D281-A64_anti-CD61(T74)-A647_ver.1.1.pdf
Target: 

CD61

Background: 

Glycoprotein IIIa, a 3 (CD61) subunit of integrin IIb3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human 3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or v3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmann’s thrombasthenia.

Size: 
50 uL/50ug
Application: 
FCM
Conjugate: 
Alexa647
Product Type: 
Primary Antibody
Species Reactivities: 
Human
Storage Temp. (°C): 
4
Shipping Temp. (°C): 
4
Pictures: 
CD61-Alexa Fluor®647
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References: 

1) Katagiri, Y., et al., J. Biol. Chem. 270, 1785-1790 (1995) 2) Prandini, M. H., et al., Biochem. Biophys. Res. Commun. 156, 595-601 (1988) 3) Zimrin, A. B., et al., J. Clin. Invest. 81, 1470-1475 (1988) 4) Kunicki, T. J., et al., J. Clin. Invest. 67, 717-724 (1981)

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