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CD61

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Code No: D281-3
Datasheet: 
application/pdf iconD281-3_anti-CD61(T74)_ver.1.pdf
FID:12087 | PATH:sites/default/files/datasheets/D281-3_anti-CD61(T74)_ver.1.pdf
Target: 

CD61

Background: 

Glycoprotein IIIa, a ?3 (CD61) subunit of integrin ?IIb?3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human ?3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or ?v?3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmannﾒs thrombasthenia.

Size: 
100 uL/100ug
Application: 
FCM
Clone Number: 
T74
Product Type: 
Primary Antibody
Species Reactivities: 
Human
Storage Temp. (°C): 
-20
Shipping Temp. (°C): 
4
Pictures: 
CD61
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References: 

1) Katagiri, Y., et al., J. Biol. Chem. 270, 1785-1790 (1995)
2) Prandini, M. H., et al., Biochem. Biophys. Res. Commun. 156, 595-601 (1988)
3) Zimrin, A. B., et al., J. Clin. Invest. 81, 1470-1475 (1988)
4) Kunicki, T. J., et al., J. Clin. Invest. 67, 717-724 (1981)

Reactivity: 
It is reported that this clone (T74) recognizes human CD61 antigen in the reference number 1).
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