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CD42b-Alexa647

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Code No: D274-A64
Datasheet: 
application/pdf iconD274-A64_anti-CD42b-Alexa647_ver.1.1.pdf
FID:15094 | PATH:sites/default/files/datasheets/D274-A64_anti-CD42b-Alexa647_ver.1.1_0.pdf
Target: 

CD42b

Background: 

The platelet glycoprotein GPIb/IX/V complex functions as a receptor for the von Willebrand factor (vWf) and thrombin. The GPIb/IX/V complex comprises GPIb, GPIb, GPIX (CD42a), and GPV (CD42d) in the ratio 2:2:2:1. GPIb (CD42b/c) is a heterodimer, composed of GPIb (CD42b) and GPIb (CD42c), covalently associated by a disulfide bond. A monoclonal antibody, TM60, specifically recognizes human GPIb (CD42b) and inhibits ristocetin-induced platelet aggregation and vWf-binding. It also inhibits thrombin-induced platelet aggregation. TM60 fails to bind to platelets from patients with Bernard-Soulier syndrome.

Size: 
50 uL/50ug
Application: 
FCM
Conjugate: 
Alexa647
Product Type: 
Primary Antibody
Species Reactivities: 
Human
Storage Temp. (°C): 
4
Shipping Temp. (°C): 
4
Pictures: 
CD42b-Alexa647
Related Products: 

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References: 

1) Cauwenberghs, N., et. al., Blood 98, 652-660 (2001) 2) Greco, N. J., et al., Biochemistry 35, 906-914 (1996) 3) Arai, M., et al., Br. J. Haematol. 87, 185-188 (1994) 4) Yamamoto, N., et al., Thromb. Res. 39, 751-759 (1985)

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