CD42b

Datasheet:

D274-3_anti-CD42b_ver.1.pdf

Target:

CD42b

Background:

The platelet glycoprotein GPIb/IX/V complex functions as a receptor for the von Willebrand factor (vWf) and thrombin. The GPIb/IX/V complex comprises GPIb, GPIb, GPIX (CD42a), and GPV (CD42d) in the ratio 2:2:2:1. GPIb (CD42b/c) is a heterodimer, composed of GPIb (CD42b) and GPIb (CD42c), covalently associated by a disulfide bond. A monoclonal antibody, TM60, specifically recognizes human GPIb (CD42b) and inhibits ristocetin-induced platelet aggregation and vWf-binding. It also inhibits thrombin-induced platelet aggregation. TM60 fails to bind to platelets from patients with Bernard-Soulier syndrome. The recognition epitope of TM60 is conformational; thus, it is impossible to use for western blot analysis.

Size:

100 uL/100ug

Application:

FCM

Product Type:

Primary Antibody

Species Reactivities:

Human

Isotype:

IgG2a κ

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

Pictures:

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References:

1) Cauwenberghs, N., et. al., Blood 98, 652-660 (2001)
2) Greco, N. J., et al., Biochemistry 35, 906-914 (1996)
3) Arai, M., et al., Br. J. Haematol. 87, 185-188 (1994)
4) Yamamoto, N., et al., Thromb. Res. 39, 751-759 (1985)

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