Solutions for Life Science & Diagnostics
Anti-GITR (Mouse) mAb (Functional grade)
Additional Information
Anti-GITR (Mouse) mAb (Functional grade) Specifications
| Background: | GITR [Glucocorticoid-Induced Tumor necrosis factor (TNF) receptor family-Related gene], also known as TNFRSF18 or AITR, is a glycoprotein homodimer. GITR is a costimulatory receptor that plays an important role in regulatory T-cell functions, including T cell proliferation and TCR-mediated apoptosis. GITR induces NF-ï«B activation via TRAF2/NIK signaling. GITR also plays a key role in immunological self-tolerance maintained by CD25+CD4+ T cells. These cells express high levels of GITR and stimulation through GITR inhibits their suppressor function, suggesting GITR could be a target for preventing or treating autoimmune disease. Activation of T and B lymphocytes upregulates GITR expression, and a GITR ligand has been detected on B lymphocytes, macrophages, and dendritic cells. Administration of the anti-GITR monoclonal antibody DTA-1 produced organ-specific autoimmune disease in normal mice. This antibody delivers an agonistic signal that eliminates suppression by regulatory T cells without causing depletion in vivo. A single administration of DTA-1 to tumor-bearing mice provoked potent tumor-specific immunity and eradicated established tumors without eliciting overt autoimmune disease. |
| Clonality: | Monoclonal |
| Clone Number: | DTA-1 |
| Formulation: | 5 mg/mL in PBS |
| Gene ID Human: | 8784 |
| Gene ID Mouse: | 21936 |
| Host Species: | Rat |
| Immunogen: | CD25+CD4+ T cells |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 500 ug |
| Species Reactivities: | Mouse |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | GITR |
Applications: 0
| Function: | Block the mouse GITR in vivo |
There are no references for Anti-GITR (Mouse) mAb (Functional grade) at this time.
