Solutions for Life Science & Diagnostics
Anti-Sap155 mAb
Additional Information
Anti-Sap155 mAb Specifications
| Alternative Names: | SF3B1; splicing factor 3b, subunit 1, 155kDa |
| Background: | SF3 is a U2 snRNP-associated protein complex essential for spliceosome assembly and splicing catalysis of the major spliceosome. SF3 contains the Spliceosome-Associated Proteins, Sap 49, 130, 145, and 155. Sap155/Sf3b1 is an essential subunit of the U2 snRNP for mRNA splicing and has also been identified in the minor (U12-dependent) spliceosome. Sap155 interacts with the mammalian PcG (Polycomb group) proteins, Mel18 and Ring1B by the yeast two hybrid system. Sap155 contains numerous Cdk consensus phosphorylation sites in its N terminus and is phosphorylated prior to catalytic step II of the splicing pathway. Sap155 serves as a substrate for cyclin E-cdk2 in vitro, suggesting that pre-mRNA splicing may be linked to the cell cycle machinery in mammalian cells. |
| Clonality: | Monoclonal |
| Clone Number: | 16 |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 23451 |
| Gene ID Mouse: | 81898 |
| Host Species: | Mouse |
| Immunogen: | Recombinant Sap155 (98-198 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | SAP155 |
Applications: IC, IP, WB
| ICC: | 10 ug/mL |
| IPP: | 1 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL |
There are no references for Anti-Sap155 mAb at this time.
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