Solutions for Life Science & Diagnostics
Anti-Histone H2B mAb
Additional Information
Anti-Histone H2B mAb Specifications
| Background: | The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The N-terminal tail of core histones undergoes multIPPle different post-translational modifications including acetylation, phosphorylation, ubiquitination, methylation, and ADP-ribosylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. Acetylation of histone H2B was suppressed to greater extent than that of the others, with histone H3 being relatively least affected. The analysis of acetylation status of each of the four lysine sites at the N-terminal tail of histone H2B revealed decreases consistent with those observed in the total acetylation patterns, with the K12 and K20 residues being markedly more affected than K5 and K15 residues. |
| Clonality: | Monoclonal |
| Clone Number: | C14264 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Host Species: | Mouse |
| Immunogen: | Protein fraction extracted from the mitotic chromosome |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse, Rat, Hamster |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | Histone H2B |
Applications: IC, IP, WB
| ICC: | 1 ug/mL |
| IPP: | 2 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-Histone H2B mAb at this time.
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