Solutions for Life Science & Diagnostics
Anti-Aggrus (Podoplanin) (Mouse) mAb
Additional Information
Anti-Aggrus (Podoplanin) (Mouse) mAb Specifications
| Alternative Names: | Pdpn; podoplanin |
| Background: | In addition to hemostasis and host defense, platelets are involved in the induction of inflammation, tissue repair, and tumor metastasis. Aggrus (T1ï¡/Podoplanin) is a novel 36-45 kDa membrane sialoglycoprotein that induces platelet aggregation. Aggrus is highly expressed in various tumor cells and the platelet aggregation ability of Aggrus depends on specific oligosaccharide structures that may be related to the metastasis process in cancer cells. Aggrus has been identified as a diagnostic tumor marker for seminomas and testicular cancers. |
| Clonality: | Monoclonal |
| Clone Number: | 8F11 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 10630 |
| Gene ID Mouse: | 14726 |
| Host Species: | Rat |
| Immunogen: | NL-17 cell membrane fraction |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Reactivity: | This antibody reacts with mouse Aggrus (Podoplanin) (44 kDa) on Western blotting, Immunoprecipitation and Flow cytometry. |
| Shipping: | 4 |
| Size: | 100 μg |
| Source: | This antibody was purified from hybridoma (clone 8F11) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell P3X63-Ag8U1 with Sprague-Dawle rat splenocyte immunized with NL-17 cell membrane fraction. |
| Species Reactivities: | Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | PDPN |
Applications: FCM, IH, IP, WB
| FCM: | 5-10 μg/mL (final concentration) |
| IHC: | 1.25 μg/mL (whole mount) |
| IPP: | 1 μg/200 μL of cell extract from 5x106< |
| WB: | 1 μg/mL (for chemiluminescence detection system |
1) Konishi, S., et al., In Vitro Cell Dev. Biol. Anim. 47, 45-53 (2011) 2) Kato, Y., et al., Cancer Sci. 99, 54-61 (2008) 3) Kunita, A., et al., Am. J. Pathol. 170, 1337-1347 (2007) 4) Katayama, K., et al., Mol. Cell. Biol. 25, 5725-5737 (2005) 5) Kaneko,
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