Solutions for Life Science & Diagnostics
Anti-CD184 (CXCR4) mAb-FITC
Additional Information
Anti-CD184 (CXCR4) mAb-FITC Specifications
| Background: | CXCR4/CD184/LESTR/fusin/NPY3R is a G protein- coupled receptor for the CXC chemokine SDF-1. Binding of SDF-1 induces CXCR4 phosphorylation by Ser/Thr kinases, leading to CXCR4 internalization via clathrin-coated pits. CXCR4 functions include co-stimulation in pre-B cell proliferation, induction of apoptosis, and HIV entry, since CXCR4 is one of the 2 major HIV/SIV co-receptors. Early infection with HIV-1 is dominated by CCR5-tropic (R5) viruses. The evolution of CXCR4-tropic (X4) viruses occurs later in the infection and is associated with rapid disease progression. CXCR4 mediates chemotaxis in mature and progenitor blood cells and is essential for B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. Although ubiquitously expressed in blood and tissue cells, its role in blood and tissue homeostasis is not fully understood. CD184 is predominantly stored intracellularly, and may contribute to the inefficiency in transmission and propagation of X4-tropic viruses |
| Clonality: | Monoclonal |
| Clone Number: | A145 |
| Conjugate: | FITC |
| Formulation: | 0.5 mg/mL in PBS/1% BSA/0.09% sodium azide |
| Gene ID Human: | 7852 |
| Gene ID Mouse: | 12767 |
| Host Species: | Rat |
| Immunogen: | CXCR4 transfected Cos-1 cells |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG1 |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 1mL (50tests) |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | CD184 |
Applications: FCM
| FCM: | 10-20 μg/mL (final concentration) |
There are no references for Anti-CD184 (CXCR4) mAb-FITC at this time.
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