Alexa Fluor®488-anti-CX3CR1 Monoclonal Antibody

Datasheet:

Target:

CX3CR1

Background:

There are several subfamilies in the chemokine superfamily. In addition to CXC, CC, and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes.
CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor families, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion.

Size:

100 µL

Application:

FCM

Product Type:

Primary Antibody

Species Reactivities:

Human

Related Products:

D070-3 anti-Human CX3CR1 (2A9-1)
D070-4 FITC labeled anti-Human CX3CR1 (2A9-1)
D070-5 PE labeled anti-Human CX3CR1 (2A9-1)
D063-3 anti-Human CCR1 (#141-2)
D063-5 PE labeled anti-Human CCR1 (#141-2)
D085-3 anti-Human CCR3 (444-11)
D085-4 FITC labeled anti-Human CCR3 (444-11)
D085-5 PE labeled anti-Human CCR3 (444-11)
D123-3 anti-Human CXCR4 (A145)
D123-4 FITC labeled anti-Human CXCR4 (A145)
D124-3 anti-Human CCR5 (T227)
D124-4 FITC labeled anti-Human CCR5 (T227)
D074-3 anti-Human CCR7 (6B3)
K0223-3 anti-CXCR7/RDC (9C4)
M090-3 Rat IgG2b isotype control (3G8)
M090-4 FITC labeled Rat IgG2b isotype control (3G8)

References:

1) Pachot, A., et al., J. Immunol. 180, 6421-6429 (2008)
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Reactivity:

This antibody reacts with human CX3CR1 on Flow cytometry.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

Product Catalog

Alexa Fluor®488-anti-CX3CR1 Monoclonal Antibody

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