Human S100A1 Specifications
|Background:||S100A1 belongs to a multigenic family of small (Mr 9-13 kDa), nonubiquitous Ca2+-sensing proteins of the EF-hand type that comprises 22 members showing 25 to 65% sequence identity. S100 proteins, which exhibit a cell- and tissue-specific expression pattern, play a major role in intracellular Ca2+-homeostasis. In addition, they have been linked to the Ca2+-dependent regulation of a variety of intracellular activities such as cell proliferation and differentiation or the dynamics of cytoskeletal constituents. S100A1 is the most abundant S100 protein in striated muscle and predominantly expressed in the adult heart. Recent gain-of-function experiments have shown that increasing intracellular S100A1 protein levels in the adult heart and skeletal muscle resulted in enhanced Ca2+-cycling and contractile function in vitro and in vivo.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for Human S100A1 at this time.